General description

A prototypic P2X₇ purinergic receptor agonist that exhibits about 3-fold higher agonistic potency for induction of nucleotide channels than ATP (EC₅₀ = 15 µM vs 50 µM). Serves as a photo-affinity analog of ATP. Its agonistic activity is significantly reduced in the presence of serum albumin. Can serve as a substrate analog for submitochondrial particle ATPase activity (Km = 940 µM). Induces a dose-dependent decrease in wild-type murine neural progenitor cell viability and an increase in caspase-3 activity. These effects are not observed in P2X₇-/- mice.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Messemer, N., et al. 2013. Neuropharmacology. 73, 122.Michel, A.D., et al. 2001. Br. J. Pharmacol.132, 1501.Erb, L., et al. 1990. J. Biol. Chem.265, 7424.r>William, N., and Coleman, P.S. 1982. J. Biol. Chem.257, 2834.

Packaging

1 mg in Glass bottle

Warning

Toxicity: Standard Handling (A)